1-Fluoro-2-nitrobenzene → Methyl 3-(2-nitroanilino)thiophene-2-carboxylate

HRID 1764232Notes

Reaction equation

HRID 1764232 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[NH2:11][C:12]1[CH:16]=[CH:15][S:14][C:13]=1[C:17]([O:19][CH3:20])=[O:18]>C1(C)C=CC=CC=1.CO>[N+:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:11][C:12]1[CH:16]=[CH:15][S:14][C:13]=1[C:17]([O:19][CH3:20])=[O:18])([O-:10])=[O:9]

Participants

4

Reactant 2

HCID 738951-Fluoro-2-nitrobenzeneHCID 89652Methyl 3-amino-2-thiophenecarboxylate

Product 1

HCID 20387689Methyl 3-(2-nitroanilino)thiophene-2-carboxylate

Reagents, catalysts & solvents 1

HCID 21867641Toluene methanolSolvent

Procedure

The title compound was prepared using the process of Example 1(a) but with 2-fluoro-nitrobenzene and methyl 3-aminothiophene-2-carboxylate (U.K. Pat. No. 837,086) as starting materials, m.p. 184° C., (toluene/MeOH, 2:1).

Sources & evidence

ORD record
ord-d477831edc4542a0bf3d418eb9536e3f
Source dataset
uspto-grants-1978_09
Patent number
US04115568

Reaction notes

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