Decanoyl chloride → HCID 20387743, compound

HRID 1764256Notes

Reaction equation

[OH:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[C:12]3[S:24][CH:23]=[CH:22][C:13]=3[NH:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)[CH2:7][CH2:6]1.[C:25]([Cl:36])(=[O:35])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>C1C=CC=CC=1>[ClH:36].[C:25]([O:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][N:8]([C:11]2[C:12]3[S:24][CH:23]=[CH:22][C:13]=3[NH:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)[CH2:9][CH2:10]1)(=[O:35])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]

Participants

Conditions

Temperature: 75 °C

Procedure

To a solution of 10-[4-(3-hydroxypropyl)-1-piperazinyl]-4H-thieno[3,2-b][1,5]benzodiazepine (1.71 g, 0.005 mol) in dry benzene (40 ml) was added decanoyl chloride (1.42 g, 0.0075 mol) in benzene (10 ml) dropwise with stirring and the solution heated at 75° C. until the reaction had gone to completion by TLC. The reaction mixture on washing gave the title compound.

Workup

washThe reaction mixture on washing

Sources & evidence

ORD record: ord-a776ae01a31148b0b571523734c06225
Source dataset: uspto-grants-1978_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04115568

Reaction notes

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