Hydrochloric Acid → HCID 20315354, compound

HRID 1764303Notes

Reaction equation

HRID 1764303 reaction equation
[CH3:1][Mg]I.[Cl:4][C:5]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:6]=1[CH:12]([CH2:15][CH2:16][CH2:17][CH3:18])[CH:13]=[O:14].O.Cl>CCOCC>[Cl:4][C:5]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:6]=1[CH:12]([CH2:15][CH2:16][CH2:17][CH3:18])[CH:13]([OH:14])[CH3:1]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 86735890HCID 86735890, compoundHCID 178418373HCID 178418373, compound

Product 1

HCID 20315354HCID 20315354, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To 14.3 g (0.088 mole) of methylmagnesium iodide in 75 ml of ether is slowly added at less than 10°, 14.5 g (0.059 mole) of the α-(2,4-dichlorophenyl) hexanal. When the addition is complete, the reaction is stirred for 1 hour then heated up to reflux for 2 hours. The reaction is cooled and poured into water. The mixture is acidified with hydrochloric acid and the oil which separates is extracted out with ether. The ether solution is dried and concentrated to give 11.7 g (76%) of the crude product.

Workup

  1. additionWhen the addition
  2. temperaturethen heated up
  3. temperatureto reflux for 2 hours
  4. temperatureThe reaction is cooled
  5. extractionthe oil which separates is extracted out with ether
  6. dry with materialThe ether solution is dried
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-4e6afa5c4b3348209f63b02184c87366
Source dataset
uspto-grants-1978_09
Patent number
US04115578

Reaction notes

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