Benzoyl chloride → benzamide, N-(2-hydroxy-1,1-dimethylethyl)-

HRID 1764321Notes

Reaction equation

HRID 1764321 reaction equation
[NH2:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].[C:7](Cl)(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>ClCCl>[C:7]([NH:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 118072-Amino-2-methyl-1-propanol

Product 1

HCID 639965benzamide, N-(2-hydroxy-1,1-dimethylethyl)-

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a 250 ml dichloromethane solution containing 89 g (1.0 mol) 2-amino-2-methyl-1-propanol at 0° was added dropwise with stirring 70 g (0.5 mol) benzoyl chloride in 250 ml dichloromethane. The reaction mixture was warmed to room temperature and stirred for several hours. The 2-amino-2-methyl-1-propanol hydrochloride was removed from the reaction mixture by filtration and was thoroughly washed with dichloromethane. The filtrate and washings were combined and the dichloromethane removed under reduced pressure to afford 67.55 g (0.35 mol), 70%, 2-benzoylamino-2-methyl-1-propanol as a white solid, mp 80°-82°, sublimation at 75° (0.2 mm); ir (KBr) 1630 (c=o) cm-1 ; pmr (CDCl3) δ 1.50 (s, 6H), 3.67 (s, 2H), 5.27 (bs, 1H), 6.92 (bs, 1H) and 7.1 - 8.3 (m, 5H) ppm.

Workup

  1. additionwas added dropwise
  2. customThe 2-amino-2-methyl-1-propanol hydrochloride was removed from the reaction mixture by filtration
  3. washwas thoroughly washed with dichloromethane
  4. customthe dichloromethane removed under reduced pressure

Sources & evidence

ORD record
ord-2a1b8761637d462a9203d96ddf655171
Source dataset
uspto-grants-1978_09
Patent number
US04115588

Reaction notes

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