1-(Benzylamino)-3-[(3-methylpyridin-2-yl)oxy]propan-2-ol → 1-Amino-3-[(3-methylpyridin-2-yl)oxy]propan-2-ol

HRID 1764346Notes

Reaction equation

HRID 1764346 reaction equation
C([NH:8][CH2:9][CH:10]([OH:20])[CH2:11][O:12][C:13]1[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][N:14]=1)C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[NH2:8][CH2:9][CH:10]([OH:20])[CH2:11][O:12][C:13]1[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][N:14]=1

Participants

4

Reactant 1

HCID 204833981-(Benzylamino)-3-[(3-methylpyridin-2-yl)oxy]propan-2-ol

Product 1

HCID 204835331-Amino-3-[(3-methylpyridin-2-yl)oxy]propan-2-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Catalytic debenzylation of a solution of 28.3 g of 2-(3'-benzylamino-2'-hydroxy-propoxy)-3-methyl-pyridine in 300 ml of ethyl acetate, with the addition of a total of 12 g of palladium on charcoal (5% strength), gives 2-(3'-amino-2'-hydroxy-propoxy)-3-methylpyridine of boiling point 120°-130° C./0.07 mm Hg in a bulb tube.

Sources & evidence

ORD record
ord-482d6936ad23448a839258636a56b2f7
Source dataset
uspto-grants-1978_09
Patent number
US04115575

Reaction notes

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