Ethanethiol → Hydrochloric Acid

Participants

Reaction Steps

13.0 g of 3-chloro-2-(3-tert.-butylamino-2-hydroxy-1-propyloxy)-pyrazine, 4.65 g of ethylmercaptan and 4.05 g of sodium methylate in 250 ml of methanol are refluxed for 30 hours. After processing according to Example 8, there is obtained 14.0 g of crude base, and from this, with ethereal hydrochloric acid, there is obtained 3-ethylthio-2-(3'-tert.-butylamino-2'-hydroxy-1-propyloxy)-pyrazine-hydrochloride, which is recrystallised from methanol/ether; m.p 147°-148°.

Provenance & Evidence