Ethanethiol → Hydrochloric Acid

HRID 1764356Notes

Reaction equation

HRID 1764356 reaction equation
[Cl:1][C:2]1[C:3]([O:8][CH2:9][CH:10]([OH:17])[CH2:11][NH:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[N:4][CH:5]=[CH:6][N:7]=1.[CH2:18]([SH:20])[CH3:19].C[O-].[Na+]>CO>[ClH:1].[ClH:1].[CH2:18]([S:20][C:2]1[C:3]([O:8][CH2:9][CH:10]([OH:17])[CH2:11][NH:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[N:4][CH:5]=[CH:6][N:7]=1)[CH3:19]

Participants

6

Reactant 3

HCID 6343EthanethiolHCID 10942334Sodium MethoxideHCID 20483524HCID 20483524, compound

Product 2

HCID 313Hydrochloric AcidHCID 20483473HCID 20483473, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

13.0 g of 3-chloro-2-(3-tert.-butylamino-2-hydroxy-1-propyloxy)-pyrazine, 4.65 g of ethylmercaptan and 4.05 g of sodium methylate in 250 ml of methanol are refluxed for 30 hours. After processing according to Example 8, there is obtained 14.0 g of crude base, and from this, with ethereal hydrochloric acid, there is obtained 3-ethylthio-2-(3'-tert.-butylamino-2'-hydroxy-1-propyloxy)-pyrazine-hydrochloride, which is recrystallised from methanol/ether; m.p 147°-148°.

Workup

  1. customthere is obtained 14.0 g of crude base

Sources & evidence

ORD record
ord-6698866b57fa44349b96e007ac0f9a66
Source dataset
uspto-grants-1978_09
Patent number
US04115575

Reaction notes

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