反应详情

温度

60 °C

A mixture of 2-(3,5-dimethylphenoxy)-butyric acid [849 g (4.1 moles)], 1075 ml toluene, and 8 ml dimethylformamide was heated to 60° C. in a 5-liter flask fitted with a gas inlet tube, a stirrer, a thermometer and a dry ice condenser. Phosgene, 472 g (4.8 moles), was passed into the solution at 60°-70° C. The mixture was then heated at 60°-70° C. for thirty minutes. The dry ice condenser was then replaced with a water-cooled condenser and the solution was purged with nitrogen to remove excess phosgene and HCl. After 2 hours, purging was discontinued and the solution was vacuum stripped to leave 2-(3,5-dimethylphenoxy)butyryl chloride, 931 g (101% yield), nD30 1.5050.

1. customfitted with a gas inlet tube, a stirrer
2. customwas passed into the solution at 60°-70° C
3. temperatureThe mixture was then heated at 60°-70° C. for thirty minutes
4. temperaturecooled condenser
5. customthe solution was purged with nitrogen
6. customto remove excess phosgene and HCl
7. custompurging