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HRID1764425

反应详情

EQUATION

反应方程式

HRID 1764425 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)O.CCN
HCID12203875

Ethanamine, acetate

C4H11NO2

结构：Cc1nc(N[N+](=O)[O-])[nH]c(=O)c1CC(C)C
HCID136388422

未命名化合物

PRODUCTS

生成物

1
结构：CCNc1nc(C)c(CC(C)C)c(=O)[nH]1
HCID135735593

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度
120 °C

PROCEDURE

实验过程

5-Isobutyl-6-methyl-2-nitraminopyrimid-4(3H)-one (16.0 g) was mixed with ethylamine acetate (30 g) and heated without solvent at 120° C for 6 hours. The melt was cooled and water was added. The mixture was brought to pH 5 and the precipitated product recrystallised from aqueous acetone to give 2-ethylamino-5-isobutyl-6-methylpyrimid-4(3H)-one (formula VII, R1 = CH3, R = is C4H9, R6 = H, R7 = C2H5) having a melting point of 203°-204° C.

WORKUP

后处理

  1. temperatureThe melt was cooled
  2. customthe precipitated product recrystallised from aqueous acetone