Ethanamine, acetate → 2-ethylamino-5-isobutyl-6-methylpyrimid-4(3H)-one
Reaction equation
[CH2:1]([C:5]1[C:6](=[O:16])[NH:7][C:8]([NH:12][N+]([O-])=O)=[N:9][C:10]=1[CH3:11])[CH:2]([CH3:4])[CH3:3].[C:17](O)(=O)[CH3:18].C(N)C>O>[CH2:17]([NH:12][C:8]1[NH:7][C:6](=[O:16])[C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])=[C:10]([CH3:11])[N:9]=1)[CH3:18]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 120 °C
Procedure
5-Isobutyl-6-methyl-2-nitraminopyrimid-4(3H)-one (16.0 g) was mixed with ethylamine acetate (30 g) and heated without solvent at 120° C for 6 hours. The melt was cooled and water was added. The mixture was brought to pH 5 and the precipitated product recrystallised from aqueous acetone to give 2-ethylamino-5-isobutyl-6-methylpyrimid-4(3H)-one (formula VII, R1 = CH3, R = is C4H9, R6 = H, R7 = C2H5) having a melting point of 203°-204° C.
Workup
- temperatureThe melt was cooled
- customthe precipitated product recrystallised from aqueous acetone
Sources & evidence
- ORD record
- ord-9efda7967c1f4c6289b5252603162d76
- Source dataset
- uspto-grants-1978_09
- Patent number
- US04116674
Reaction notes
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