HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1764425Generated: November 1, 2026
Ethanamine, acetate → 2-ethylamino-5-isobutyl-6-methylpyrimid-4(3H)-one
https://huagongshe.com/reaction/1764425
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanamine, acetate | HCID 12203875 | — |
| Reactant | 5-isobutyl-6-methyl-2-nitraminopyrimid-4(3H)-one | HCID 136388422 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-ethylamino-5-isobutyl-6-methylpyrimid-4(3H)-one | HCID 135735593 | — |
Reaction Steps
5-Isobutyl-6-methyl-2-nitraminopyrimid-4(3H)-one (16.0 g) was mixed with ethylamine acetate (30 g) and heated without solvent at 120° C for 6 hours. The melt was cooled and water was added. The mixture was brought to pH 5 and the precipitated product recrystallised from aqueous acetone to give 2-ethylamino-5-isobutyl-6-methylpyrimid-4(3H)-one (formula VII, R1 = CH3, R = is C4H9, R6 = H, R7 = C2H5) having a melting point of 203°-204° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04116674 |
|---|
| Source dataset | uspto-grants-1978_09 |
|---|
| ORD ID | ord-9efda7967c1f4c6289b5252603162d76 |
|---|
| Source note | uspto-grants-1978_09 |
|---|
