2-Propen-1-amine, acetate → HCID 136388423, compound

HRID 1764426Notes

Reaction equation

HRID 1764426 reaction equation
C(O)(=O)C.[CH2:5]([NH2:8])[CH:6]=[CH2:7].[CH3:9][C:10]1[N:15]=[C:14](SC)[NH:13][C:12](=[O:18])[C:11]=1[CH2:19][CH2:20][CH3:21]>O>[CH2:5]([NH:8][C:14]1[NH:13][C:12](=[O:18])[C:11]([CH2:19][CH2:20][CH3:21])=[C:10]([CH3:9])[N:15]=1)[CH:6]=[CH2:7]

Participants

4

Reactant 2

HCID 122036582-Propen-1-amine, acetateHCID 1357355926-Methyl-2-(methylsulfanyl)-5-propylpyrimidin-4(1H)-one

Product 1

HCID 136388423HCID 136388423, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

A mixture of allylamine acetate (12 g) and 6-methyl-2-methylthio-5-propylpyrimid-4(3H)-one (6 g) was heated at 130° C for 45 minutes. The mixture was cooled and water was added. The precipitated product was collected, washed with water, dried and recrystallised from petroleum (b.p. 80°-100° C) giving 2-allylamino-6-methyl-5-propylpyrimid-4(3H)-one (formula VII, R1 = CH3, R = C3H7, R6 = H, R7 = CH2CH=CH2) having a melting point of 152°-153° C.

Workup

  1. temperatureThe mixture was cooled
  2. customThe precipitated product was collected
  3. washwashed with water
  4. customdried
  5. customrecrystallised from petroleum (b.p. 80°-100° C)

Sources & evidence

ORD record
ord-a62dc830bb78446a90f7b1808986b1be
Source dataset
uspto-grants-1978_09
Patent number
US04116674

Reaction notes

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