HRID1764433

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3084017

Methyl DL-phenylalaninate hydrochloride

C10H14ClNO2

结构：O=C(N[C@H](C(=O)O)C(Cc1ccccc1)C(=O)O)OCc1ccccc1

HCID53769026

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(Cc1ccccc1)C(=O)O

HCID14876780

未命名化合物

收率 45.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The process of Example 51 was repeated except that 357 mg (1.00 mmol) of N-benzyloxycarbonyl-(β-benzyl)-L-aspartic acid and 431 mg (2.00 mmol) of D,L-phenylalanine methyl ester hydrochloride were reacted. As a result, a 238 mg amount (yield of 45.8%) of N-benzyloxycarbonyl (β-benzyl)-L-aspartyl-L-phenylalanine methyl ester having an [α]D20 = -13.2 (C=1.0 dimethylformamide) was obtained.

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9188b72c23b74a11957d88f684bd7585
来源数据集: uspto-grants-1978_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04116768
来源说明: uspto-grants-1978_09

反应 SMILES

[CH2:1]([O:8][C:9]([NH:11][C@H:12]([C:24](O)=[O:25])[CH:13]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:14]([OH:16])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH3:28][O:29][C:30](=[O:40])[CH:31]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[NH2:32]>CN(C)C=O>[CH3:28][O:29][C:30](=[O:40])[C@H:31]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[NH:32][C:24](=[O:25])[C@H:12]([CH:13]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:14](=[O:15])[OH:16])[NH:11][C:9]([O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:10]