反应详情

An ethereal solution (1 liter) containing 50.0 g (0.22 mol) of methyl 2-hydroxy-3-phenylbenzoate, 0.25 mole of methanesulfonyl chloride and 0.25 mole of Et3N was allowed to react at room temperature for 18 hours. The reaction mixture was washed with 1 N NaOH (1 × 1 liter) and H2O (1 × 500 ml). After drying with MgSO4 the ether solution was evaporated to give a yellow solid; yield 61.9 g (91.7%), mp. 101°-115°. Recrystallization of the crude product from benzene-hexane gave the analytical sample, mp. 120°-124°.

1. customto react at room temperature for 18 hours
2. washThe reaction mixture was washed with 1 N NaOH (1 × 1 liter) and H2O (1 × 500 ml)
3. dry with materialAfter drying with MgSO4 the ether solution
4. customwas evaporated
5. customto give a yellow solid
6. customRecrystallization of the crude product from benzene-hexane
7. customgave the analytical sample, mp. 120°-124°