反应详情

2-Amino-5-fluorothiazole (19.0 grams) and a saturated solution of phosgene in ethyl acetate (200 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated at reflux with stirring for a period of about 3 hours. After this time the reaction mixture is cooled and filtered to recover the desired product 5-fluorothiazol-2-yl isocyanate dimer.

1. customequipped with a mechanical stirrer
2. temperaturethermometer and reflux condenser
3. temperatureThe reaction mixture is heated
4. temperatureat reflux
5. temperatureAfter this time the reaction mixture is cooled
6. filtrationfiltered
7. customto recover the desired product 5-fluorothiazol-2-yl isocyanate dimer