Ethanol → HCID 22768402, compound

Participants

Reaction Steps

To a mixture of 9.1 parts of 2-amino-5-phenyl-7-trifluoromethyl-3H-1,4-benzodiazepine, 150 parts by volume of ethanol and 3.6 parts by volume of glacial acetic acid is added 4.5 parts by volume of 100% hydrazine hydrate. The whole mixture is stirred for 30 minutes at room temperature and treated in a similar manner to Example 1, whereby 2-hydrazino-5-phenyl-7-trifluoromethyl-3H-1,4-benzodiazepine is yielded as a crystalline powder. Melting point: 127° C (sintering), 133° C to 135° C (effervescence).

Provenance & Evidence