Ethanol → HCID 22768402, compound

HRID 1764503Notes

Reaction equation

HRID 1764503 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]2[CH:15]=[C:16]([C:19]([F:22])([F:21])[F:20])[CH:17]=[CH:18][C:4]=2[N:3]=1.C(O)C.O.[NH2:27]N>C(O)(=O)C>[NH:1]([C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:5]2[CH:15]=[C:16]([C:19]([F:22])([F:20])[F:21])[CH:17]=[CH:18][C:4]=2[N:3]=1)[NH2:27]

Participants

5

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 15079734HCID 15079734, compound

Product 1

HCID 22768402HCID 22768402, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a mixture of 9.1 parts of 2-amino-5-phenyl-7-trifluoromethyl-3H-1,4-benzodiazepine, 150 parts by volume of ethanol and 3.6 parts by volume of glacial acetic acid is added 4.5 parts by volume of 100% hydrazine hydrate. The whole mixture is stirred for 30 minutes at room temperature and treated in a similar manner to Example 1, whereby 2-hydrazino-5-phenyl-7-trifluoromethyl-3H-1,4-benzodiazepine is yielded as a crystalline powder. Melting point: 127° C (sintering), 133° C to 135° C (effervescence).

Workup

  1. additiontreated in a similar manner to Example 1

Sources & evidence

ORD record
ord-a5ba70b604964e84b916d7f19fcb52b4
Source dataset
uspto-grants-1978_09
Patent number
US04116956

Reaction notes

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