Methanol → HCID 12570863, compound

HRID 1764504Notes

Reaction equation

HRID 1764504 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]2[CH:15]=[C:16]([CH3:19])[CH:17]=[CH:18][C:4]=2[N:3]=1.CO.O.[NH2:23]N>C(O)(=O)C>[NH:1]([C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:5]2[CH:15]=[C:16]([CH3:19])[CH:17]=[CH:18][C:4]=2[N:3]=1)[NH2:23]

Participants

5

Reactant 3

HCID 887MethanolHCID 24654Hydrazine hydrate (1:1)HCID 12569588HCID 12569588, compound

Product 1

HCID 12570863HCID 12570863, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a mixture of 2.5 parts of 2-amino-7-methyl-5-phenyl-3H-1,4-benzodiazepine, 100 parts by volume of methanol and 1.2 parts of glacial acetic acid is added 2.5 parts of 100% hydrazine hydrate. The mixture is stirred for 1 hour at room temperature and treated in a similar manner to Example 1, whereby 2-hydrazino-7-methyl-5-phenyl-3H-1,4-benzodiazepine is yielded as crystals. Recrystallization from a mixture of chloroform and diethyl ether affords colorless crystals melting at 240° C to 241° (decomposition).

Workup

  1. additiontreated in a similar manner to Example 1

Sources & evidence

ORD record
ord-c2fee7b821b440808a8e9283b6ec572a
Source dataset
uspto-grants-1978_09
Patent number
US04116956

Reaction notes

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