HCID 12736934, compound → HCID 12736935, compound

HRID 1764631Notes

Reaction equation

HRID 1764631 reaction equation
[O:1]=[C:2]1[C:7]([C:8]([O:10]CC)=[O:9])=[CH:6][NH:5][C:4]2[O:13][C:14]3[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=3[C:16](=[O:17])[C:3]1=2>Cl>[O:1]=[C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][NH:5][C:4]2[O:13][C:14]3[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=3[C:16](=[O:17])[C:3]1=2

Participants

3

Reactant 1

HCID 12736934HCID 12736934, compound

Product 1

HCID 12736935HCID 12736935, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A suspension of ethyl 4,5-dihydro-4,5-dioxo-1H-1-benzopyrano[2,3-b]-pyridine-3-carboxylate (3.0 g, 0.011 mole) in 5N hydrochloric acid (100 ml) is refluxed under nitrogen for 16 hrs., cooled, filtered, washed with acetone and sucked dry. Recrystallization from DMF gives white crystals (2.51 g, 93%), mp 335°-340° C.

Workup

  1. temperatureis refluxed under nitrogen for 16 hrs
  2. temperature, cooled
  3. filtrationfiltered
  4. washwashed with acetone
  5. customsucked dry
  6. customRecrystallization from DMF

Sources & evidence

ORD record
ord-6e72294d07784a369c06eca3e2675e97
Source dataset
uspto-grants-1978_09
Patent number
US04117134

Reaction notes

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