Isopropylamine → 2-n-Butyl-3-[4-(2-hydroxy-3-isopropylaminopropoxy)phenylsulfonyl]benzofuran

HRID 1764664Notes

Reaction equation

HRID 1764664 reaction equation
[CH2:1]([C:5]1[O:6][C:7]2[CH:27]=[CH:26][CH:25]=[CH:24][C:8]=2[C:9]=1[S:10]([C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH:21]2[O:23][CH2:22]2)=[CH:15][CH:14]=1)(=[O:12])=[O:11])[CH2:2][CH2:3][CH3:4].[CH:28]([NH2:31])([CH3:30])[CH3:29]>C(Cl)(Cl)Cl>[CH2:1]([C:5]1[O:6][C:7]2[CH:27]=[CH:26][CH:25]=[CH:24][C:8]=2[C:9]=1[S:10]([C:13]1[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH:21]([OH:23])[CH2:22][NH:31][CH:28]([CH3:30])[CH3:29])=[CH:17][CH:18]=1)(=[O:11])=[O:12])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 227688372-n-Butyl-3-[4-(2,3-epoxypropoxy)phenylsulfonyl]benzofuran

Product 1

HCID 227688812-n-Butyl-3-[4-(2-hydroxy-3-isopropylaminopropoxy)phenylsulfonyl]benzofuran

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2-n-Butyl-3-[4-(2,3-epoxypropoxy)phenylsulfonyl]benzofuran (1.9 g.) was dissolved in 30 ml. of freshly distilled isopropylamine and the solution was heated at 100° for 2 hours. After cooling, the solvent was evaporated to give a residue which was dissolved in chloroform. Evaporation of the solvent gave the title compound.

Workup

  1. temperatureAfter cooling
  2. customthe solvent was evaporated
  3. customto give a residue which
  4. customEvaporation of the solvent

Sources & evidence

ORD record
ord-46ca60b29d5c464db13c4d25eeee43c6
Source dataset
uspto-grants-1978_09
Patent number
US04117128

Reaction notes

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