4-Methoxybenzenesulfonyl chloride → 2-(4-Chlorophenyl)-3-(4-hydroxyphenylsulfonyl)benzofuran

HRID 1764669Notes

Reaction equation

HRID 1764669 reaction equation
ClC1C=CC(C2OC3C=CC=CC=3C=2)=CC=1.COC1C=CC(S(Cl)(=O)=O)=CC=1.[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]2[O:37][C:38]3[CH:55]=[CH:54][CH:53]=[CH:52][C:39]=3[C:40]=2[S:41]([C:44]2[CH:49]=[CH:48][C:47]([O:50]C)=[CH:46][CH:45]=2)(=[O:43])=[O:42])=[CH:32][CH:31]=1>>[Cl:29][C:30]1[CH:31]=[CH:32][C:33]([C:36]2[O:37][C:38]3[CH:55]=[CH:54][CH:53]=[CH:52][C:39]=3[C:40]=2[S:41]([C:44]2[CH:49]=[CH:48][C:47]([OH:50])=[CH:46][CH:45]=2)(=[O:42])=[O:43])=[CH:34][CH:35]=1

Participants

4

Reactant 3

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 43683122-(4-Chlorophenyl)-1-benzofuranHCID 227688692-(4-Chlorophenyl)-3-(4-methoxyphenylsulfonyl)benzofuran

Product 1

HCID 227688982-(4-Chlorophenyl)-3-(4-hydroxyphenylsulfonyl)benzofuran

Procedure

Acylation of 2-(p-chlorophenyl)benzofuran with 4-methoxybenzenesulfonyl chloride as described in Example 1 followed by demethylation of the 2-(4-chlorophenyl)-3-(4-methoxyphenylsulfonyl)benzofuran thus formed also as described therein, gives 2-(4-chlorophenyl)-3-(4-hydroxyphenylsulfonyl)benzofuran.

Workup

  1. customthus formed also

Sources & evidence

ORD record
ord-8033d638734d4ee5bb74eab89d996bdb
Source dataset
uspto-grants-1978_09
Patent number
US04117128

Reaction notes

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