4-Methoxybenzenesulfonyl chloride → 3-(4-Hydroxyphenylsulfonyl)-2-(4-tolyl)benzofuran

HRID 1764671Notes

Reaction equation

HRID 1764671 reaction equation
C1(C)C=CC(C2OC3C=CC=CC=3C=2)=CC=1.COC1C=CC(S(Cl)(=O)=O)=CC=1.C[O:30][C:31]1[CH:36]=[CH:35][C:34]([S:37]([C:40]2[C:44]3[CH:45]=[CH:46][CH:47]=[CH:48][C:43]=3[O:42][C:41]=2[C:49]2[CH:54]=[CH:53][C:52]([CH3:55])=[CH:51][CH:50]=2)(=[O:39])=[O:38])=[CH:33][CH:32]=1>>[OH:30][C:31]1[CH:32]=[CH:33][C:34]([S:37]([C:40]2[C:44]3[CH:45]=[CH:46][CH:47]=[CH:48][C:43]=3[O:42][C:41]=2[C:49]2[CH:50]=[CH:51][C:52]([CH3:55])=[CH:53][CH:54]=2)(=[O:39])=[O:38])=[CH:35][CH:36]=1

Participants

4

Reactant 3

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 6384582-(p-Tolyl)benzofuranHCID 227688863-(4-Methoxyphenylsulfonyl)-2-(4-tolyl)benzofuran

Product 1

HCID 227688753-(4-Hydroxyphenylsulfonyl)-2-(4-tolyl)benzofuran

Procedure

3-(4-Hydroxyphenylsulfonyl)-2-(4-tolyl)benzofuran is prepared by acylation of 2-(4-tolyl)benzofuran with 4-methoxybenzenesulfonyl chloride followed by demethylation of the 3-(4-methoxyphenylsulfonyl)-2-(4-tolyl)benzofuran thus formed as described hereinabove.

Workup

  1. customthus formed

Sources & evidence

ORD record
ord-0f92b8fccb4d464da3a1bbaf388ac2f1
Source dataset
uspto-grants-1978_09
Patent number
US04117128

Reaction notes

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