4-Methoxybenzenesulfonyl chloride → 2-Ethyl-3-(4-hydroxyphenylsulfonyl)benzofuran

HRID 1764674Notes

Reaction equation

HRID 1764674 reaction equation
C(C1OC2C=CC=CC=2C=1)C.COC1C=CC(S(Cl)(=O)=O)=CC=1.[CH2:24]([C:26]1[O:27][C:28]2[CH:45]=[CH:44][CH:43]=[CH:42][C:29]=2[C:30]=1[S:31]([C:34]1[CH:39]=[CH:38][C:37]([O:40]C)=[CH:36][CH:35]=1)(=[O:33])=[O:32])[CH3:25]>>[CH2:24]([C:26]1[O:27][C:28]2[CH:45]=[CH:44][CH:43]=[CH:42][C:29]=2[C:30]=1[S:31]([C:34]1[CH:39]=[CH:38][C:37]([OH:40])=[CH:36][CH:35]=1)(=[O:33])=[O:32])[CH3:25]

Participants

4

Reactant 3

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 765822-EthylbenzofuranHCID 227688742-Ethyl-3-(4-methoxyphenylsulfonyl)benzofuran

Product 1

HCID 227688442-Ethyl-3-(4-hydroxyphenylsulfonyl)benzofuran

Procedure

2-Ethyl-3-(4-hydroxyphenylsulfonyl)benzofuran is prepared by acylation of 2-ethylbenzofuran with 4-methoxybenzenesulfonyl chloride followed by demethylation of the 2-ethyl-3-(4-methoxyphenylsulfonyl)benzofuran thus formed as described hereinabove.

Workup

  1. customthus formed

Sources & evidence

ORD record
ord-9f32a0fc18aa463a9509877fd137a04e
Source dataset
uspto-grants-1978_09
Patent number
US04117128

Reaction notes

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