4-Methoxybenzenesulfonyl chloride → HCID 22768858, compound

HRID 1764682Notes

Reaction equation

HRID 1764682 reaction equation
FC(F)(F)C1C=C(C=CC=1)CC1OC2C=CC=CC=2C=1.COC1C=CC(S(Cl)(=O)=O)=CC=1.C[O:34][C:35]1[CH:40]=[CH:39][C:38]([S:41]([C:44]2[C:48]3[CH:49]=[CH:50][CH:51]=[CH:52][C:47]=3[O:46][C:45]=2[CH2:53][C:54]2[CH:59]=[CH:58][CH:57]=[C:56]([C:60]([F:63])([F:62])[F:61])[CH:55]=2)(=[O:43])=[O:42])=[CH:37][CH:36]=1>>[OH:34][C:35]1[CH:36]=[CH:37][C:38]([S:41]([C:44]2[C:48]3[CH:49]=[CH:50][CH:51]=[CH:52][C:47]=3[O:46][C:45]=2[CH2:53][C:54]2[CH:59]=[CH:58][CH:57]=[C:56]([C:60]([F:63])([F:62])[F:61])[CH:55]=2)(=[O:43])=[O:42])=[CH:39][CH:40]=1

Participants

4

Reactant 3

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 22768889HCID 22768889, compoundHCID 227688952-{[3-(Trifluoromethyl)phenyl]methyl}-1-benzofuran

Product 1

HCID 22768858HCID 22768858, compound

Procedure

Acylation of 2-(3-trifluoromethylbenzyl)benzofuran with 4-methoxybenzenesulfonyl chloride as described in the procedure described above followed by demethylation of the 3-(4-methoxyphenylsulfonyl)-2-(3-trifluoromethylbenzyl)benzofuran thus formed also as described above gives 3-(4-hydroxyphenylsulfonyl)-2-(3-trifluoromethylbenzyl)benzofuran.

Workup

  1. customthus formed also

Sources & evidence

ORD record
ord-def9e6f44e5c476289b5eb632c7b77ed
Source dataset
uspto-grants-1978_09
Patent number
US04117128

Reaction notes

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