Methanol → HCID 178478705, compound

HRID 1764744Notes

Reaction equation

HRID 1764744 reaction equation
[ClH:1].Cl.[NH2:3][CH2:4][C:5]([C:7]1[N:8]=[CH:9][N:10](CC2C=CC=CC=2)[C:11]=1[NH2:12])=[O:6].CO.O.[H][H]>[Pd].C(O)(=O)C>[ClH:1].[ClH:1].[NH2:3][CH2:4][C:5]([C:7]1[N:8]=[CH:9][NH:10][C:11]=1[NH2:12])=[O:6]

Participants

7

Reactant 4

HCID 887MethanolHCID 962WaterHCID 45357346HCID 45357346, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 178478705HCID 178478705, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

A solution of 1.0 g. of 2-amino-1-[5-amino-1-(phenylmethyl)-1H-imidazol-4-yl]ethanone dihydrochloride in 100 ml. of 70:20:10 methanol:water:acetic acid is hydrogenated over 0.52 g. of 20% palladium-on-carbon at 50 p.s.i. until hydrogen uptake ceases. The catalyst is removed by filtration and the filtrate is evaporated at reduced pressure to give 2-amino-1-(5-amino-1H-imidazol-4-yl)ethanone dihydrochloride; m.p. above 250° dec.

Workup

  1. customThe catalyst is removed by filtration
  2. customthe filtrate is evaporated at reduced pressure

Sources & evidence

ORD record
ord-707a4ff2625348feb1ccf816c8d30369
Source dataset
uspto-grants-1978_09
Patent number
US04117229

Reaction notes

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