Hydrochloric Acid → HCID 178479233, compound

HRID 1764771Notes

Reaction equation

HRID 1764771 reaction equation
C([NH:4][CH2:5][CH2:6][N:7]1[C:11](=[S:12])[NH:10][N:9]=[N:8]1)(=O)C.[ClH:13]>>[ClH:13].[NH2:4][CH2:5][CH2:6][N:7]1[C:11](=[S:12])[NH:10][N:9]=[N:8]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178474870HCID 178474870, compound

Product 1

HCID 178479233HCID 178479233, compoundYield 66.1%

Procedure

A mixture of 21.5 g. (11.4 mmol) of 1-[2-(acetylamino)ethyl]-1,4-dihydro-5H-tetrazole-5-thione in 300 ml. of 6N hydrochloric acid was heated at reflux for 3.5 hours. The mixture was filtered after cooling to room temperature. The filtrate was concentrated to small volume. The residual liquid was diluted with i-propanol. The solid which precipitated was filtered, washed and dried in vacuo to give 13.7 g. of 1-(2-aminoethyl)-1,4-dihydro-5H-tetrazole-5-thione, hydrochloride (66.1% yield) mp 232°-233.5° C.

Workup

  1. additionA mixture of 21.5 g
  2. temperatureat reflux for 3.5 hours
  3. filtrationThe mixture was filtered
  4. concentrationThe filtrate was concentrated to small volume
  5. additionThe residual liquid was diluted with i-propanol
  6. customThe solid which precipitated
  7. filtrationwas filtered
  8. washwashed
  9. customdried in vacuo
  10. customto give 13.7 g

Sources & evidence

ORD record
ord-25819c90047e42fca256641ba95a3411
Source dataset
uspto-grants-1978_09
Patent number
US04117125

Reaction notes

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