反应详情

A 200-ml ethyl acetate mixture containing 1-(trans-4-ethylcyclohexyl)-3-(2,3,4-trifluorophenyl)-2-propyne-1-ol (38 g) and 5% palladium carbon (50% in water, 2 g) was stirred for 4 hours at room temperature at a hydrogen pressure of 4 atm. After palladium carbon was removed by filtration using Celite, the filtrate was concentrated to obtain 1-(trans-4-ethylcyclohexyl)-3-(2,3,4-trifluorophenyl)-1-propanol (38 g).

1. customAfter palladium carbon was removed by filtration
2. concentrationthe filtrate was concentrated