Triethylamine → HCID 21106441, compound

HRID 1765057Notes

Reaction equation

HRID 1765057 reaction equation
[C:1]1([NH:7][C:8]2[N:9]=[N:10]NC=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:14]1[CH:19]=[C:18]([Cl:20])[N:17]=[CH:16][N:15]=1.[CH2:21]([N:23](CC)CC)C>C(#N)C>[Cl:20][C:18]1[N:17]=[CH:16][N:15]=[C:14]([N:10]2[CH:21]=[N:23][C:8]([NH:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[N:9]2)[CH:19]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 709434,6-DichloropyrimidineHCID 178420479HCID 178420479, compound

Product 1

HCID 21106441HCID 21106441, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A suspension of phenylaminotriazole (3.12 mmol), 4,6-dichloropyrimidine (4.1 mmol, 1.3 equivalents) and triethylamine (4.7 mmol, 1.5 equivalents) in acetonitrile (20 ml) was stirred at reflux for eighteen hours. The reaction mixture was partitioned between ethyl acetate and brine. A white precipitate formed and was removed by filtration to afford the the title compound which was used without purification in the next step. LC-MS: [MH+] 274.

Workup

  1. temperatureat reflux for eighteen hours
  2. customThe reaction mixture was partitioned between ethyl acetate and brine
  3. customA white precipitate formed
  4. customwas removed by filtration

Sources & evidence

ORD record
ord-85b5875e9eb342009fe59d8ebef0fa97
Source dataset
uspto-grants-2007_06
Patent number
US07226920B2

Reaction notes

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