Tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate → HCID 69498039, compound

HRID 1765093Notes

Reaction equation

HRID 1765093 reaction equation
Cl[C:2]1[C:7]([O:8][CH2:9][CH2:10][O:11]C2CCCCO2)=[CH:6][CH:5]=[CH:4][N:3]=1.[OH:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22]1>>[C:30]([O:29][C:27]([N:24]1[CH2:23][CH2:22][N:21]([CH2:20][CH2:19][O:18][C:2]2[C:7]([O:8][CH2:9][CH2:10][OH:11])=[CH:6][CH:5]=[CH:4][N:3]=2)[CH2:26][CH2:25]1)=[O:28])([CH3:33])([CH3:32])[CH3:31]

Participants

3

Reactant 2

HCID 735736Tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylateHCID 211066702-Chloro-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]pyridine

Product 1

HCID 69498039HCID 69498039, compound

Procedure

The title compound was prepared starting from 2-chloro-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]pyridine (from Example 4; 0.67 g, 2.6 mmol) and tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (0.66 g, 2.9 mmol) according to the procedure in Example 23, Step 1, followed by removing the tetrahydropyranyl protecting group according to the procedure given in Example 23, Step 2. Yield 0.36 g (38%). MS (ESI+) for C18H29N3O5 m/z 368.0 (M+H)+.

Workup

  1. customby removing the tetrahydropyranyl protecting group

Sources & evidence

ORD record
ord-506dd45719034060a53eb76f4e809bf6
Source dataset
uspto-grants-2007_06
Patent number
US07226925B2

Reaction notes

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