Tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate → HCID 69498039, compound

Participants

Reaction Steps

The title compound was prepared starting from 2-chloro-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]pyridine (from Example 4; 0.67 g, 2.6 mmol) and tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (0.66 g, 2.9 mmol) according to the procedure in Example 23, Step 1, followed by removing the tetrahydropyranyl protecting group according to the procedure given in Example 23, Step 2. Yield 0.36 g (38%). MS (ESI+) for C18H29N3O5 m/z 368.0 (M+H)+.

Provenance & Evidence