HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 87886212, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2,6-Dibromopyridine | HCID 12274 | — |
| Reactant | 2-(8-Fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol | HCID 44408729 | — |
| Product | HCID 87886212 | HCID 87886212 | 60% |
Reaction Steps
2-(8-Fluoroimidazo[1,2-α]pyridin-7-yl)propan-2-ol (194 mg, 1.0 mmol) was coupled with 2,6-dibromopyridine (403 mg, 1.7 mmol) using Cs2CO3 (652 mg, 2.0 mmol), as described in Example 4, affording 2-[3-(6-bromopyridin-2-yl)-8-fluoroimidazo[1,2-α]pyridin-7-yl]propan-2-ol as a white amorphous solid (210 mg, 60%): m/z (ES+) 350, 352 (100%, [MH]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07226926B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-e645a93bbbfd4f65a5992cee4f380a06 |
| Source note | uspto-grants-2007_06 |