Cesium carbonate → HCID 87886212, compound

HRID 1765101Notes

Reaction equation

HRID 1765101 reaction equation
[F:1][C:2]1[C:3]2[N:4]([CH:12]=[CH:13][N:14]=2)[CH:5]=[CH:6][C:7]=1[C:8]([OH:11])([CH3:10])[CH3:9].[Br:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18](Br)[N:17]=1.C([O-])([O-])=O.[Cs+].[Cs+]>>[Br:15][C:16]1[N:17]=[C:18]([C:12]2[N:4]3[CH:5]=[CH:6][C:7]([C:8]([OH:11])([CH3:10])[CH3:9])=[C:2]([F:1])[C:3]3=[N:14][CH:13]=2)[CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 122742,6-DibromopyridineHCID 444087292-(8-Fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol

Product 1

HCID 87886212HCID 87886212, compoundYield 60%

Procedure

2-(8-Fluoroimidazo[1,2-α]pyridin-7-yl)propan-2-ol (194 mg, 1.0 mmol) was coupled with 2,6-dibromopyridine (403 mg, 1.7 mmol) using Cs2CO3 (652 mg, 2.0 mmol), as described in Example 4, affording 2-[3-(6-bromopyridin-2-yl)-8-fluoroimidazo[1,2-α]pyridin-7-yl]propan-2-ol as a white amorphous solid (210 mg, 60%): m/z (ES+) 350, 352 (100%, [MH]+).

Sources & evidence

ORD record
ord-e645a93bbbfd4f65a5992cee4f380a06
Source dataset
uspto-grants-2007_06
Patent number
US07226926B2

Reaction notes

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