3-Methoxyaniline → HCID 22732377, compound

HRID 1765130Notes

Reaction equation

HRID 1765130 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)[N:3]=1.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([NH2:24])[CH:19]=1>>[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH:21]=[CH:22][CH:23]=1)[NH:24][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)[N:3]=1

Participants

3

Reactant 2

HCID 108243-MethoxyanilineHCID 41892124-chloro-6-methyl-2-(3-methylphenyl)pyrimidine

Product 1

HCID 22732377HCID 22732377, compound

Procedure

The title compound was prepared from 4-chloro-6-methyl-2-(3-methylphenyl)pyrimidine (100 mg, 0.457 mmol) and m-anisidine (51 μl, 0.457 mmol) similar to Example 11 as a pale yellow solid (11 mg, 8%). 1H NMR (DMSO-d6): 8.09 (s, 1H), 8.05 (d, J=7.5 Hz, 1H), 7.54–7.49 (m, 4H), 7.35 (t, J=8.1 Hz, 1H), 7.21 (s, 1H), 6.78 (s, 2H), 3.81 (s, 3H), 2.43 (s, 6H).

Sources & evidence

ORD record
ord-647381a53d96467d9cbfe6a9e5d3bc9e
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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