3-Methoxyaniline → HCID 22732501, compound

HRID 1765131Notes

Reaction equation

HRID 1765131 reaction equation
Cl[C:2]1[C:7]([O:8][CH3:9])=[CH:6][N:5]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[N:3]=1.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([NH2:24])[CH:19]=1>>[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH:21]=[CH:22][CH:23]=1)[NH:24][C:2]1[C:7]([O:8][CH3:9])=[CH:6][N:5]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[N:3]=1

Participants

3

Reactant 2

HCID 108243-MethoxyanilineHCID 27635004-CHLORO-5-METHOXY-2-(2-PYRIDINYL)PYRIMIDINE

Product 1

HCID 22732501HCID 22732501, compound

Procedure

The title compound was prepared from 4-chloro-5-methoxy-2-(2-pyridinyl)pyrimidine (100 mg, 0.451 mmol) and m-anisidine (51 μl, 0.451 mmol) similar to Example 13 and isolated as a tan oily liquid (63 mg, 45%). 1H NMR (CDCl3): 8.76–8.74 (m, 1H), 8.37 (dd, J=1.1, 8.0 Hz, 1H), 8.05 (s, 1H), 7.79–7.73 (m, 2H), 6.65–6.62 (m, 1H), 3.92 (s, 3H), 3.84 (s, 3H).

Sources & evidence

ORD record
ord-dd36bde307be4117b26d9ef55cf99458
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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