3-Aminobenzonitrile → HCID 22732384, compound

HRID 1765139Notes

Reaction equation

HRID 1765139 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1.[NH2:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][CH:23]=1)[C:19]#[N:20]>>[C:19]([C:18]1[CH:17]=[C:16]([CH:23]=[CH:22][CH:21]=1)[NH:15][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1)#[N:20]

Participants

3

Reactant 2

HCID 167023-AminobenzonitrileHCID 27633954-Chloro-6-methyl-2-(pyridin-2-yl)pyrimidine

Product 1

HCID 22732384HCID 22732384, compound

Procedure

The title compound was prepared from 4-chloro-6-methyl-2-(2-pyridinyl)pyrimidine (100 mg, 0.486 mmol) and 3-aminobenzonitrile (57 mg, 0.486 mmol) similar to Example 11 and isolated as a pale white solid (107 mg, 76%). 1H NMR (DMSO-d6): 10.14 (s, 1H), 8.78–8.75 (m, 1H), 8.56 (s, 1H), 8.32 (d, J=7.8 Hz, 1H), 8.04–7.96 (m, 2H), 7.60–7.47 (m, 3H), 6.75 (s, 1H), 2.47 (s, 3H).

Sources & evidence

ORD record
ord-a6af89d7f7f449cc9c2d0ea645619757
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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