3-Isopropylaniline → HCID 9814966, compound

HRID 1765148Notes

Reaction equation

HRID 1765148 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1.[CH:15]([C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH2:21])([CH3:17])[CH3:16]>>[CH:15]([C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH:21][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1)([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 4586793-IsopropylanilineHCID 27633954-Chloro-6-methyl-2-(pyridin-2-yl)pyrimidine

Product 1

HCID 9814966HCID 9814966, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-6-methyl-2-(2-pyridinyl)pyrimidine (50 mg, 0.243 mmol) and 3-isopropylaniline (33 μl, 0.243 mmol) similar to Example 13 and isolated as a gray oil (70 mg, 95%). 1H NMR (CDCl3): 8.79–8.77 (m, 1H), 8.47–8.43 (m, 1H), 7.81–7.75 (m, 1H), 7.35–7.25 (m, 3H), 7.17–7.12 (m, 2H), 7.02 (d, J=7.5 Hz, 1H), 2.93–2.84 (m, 1H), 2.45 (s, 3H), 1.24 (d, J=6.9 Hz, 6H).

Sources & evidence

ORD record
ord-b92dcb2590ed4ee388103e18b8f23d17
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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