3-Methoxyphenol → HCID 22732505, compound

HRID 1765151Notes

Reaction equation

HRID 1765151 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([OH:23])[CH:20]=[CH:21][CH:22]=1>>[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:20]=[CH:21][CH:22]=1)[O:23][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1

Participants

3

Reactant 2

HCID 90073-MethoxyphenolHCID 27633954-Chloro-6-methyl-2-(pyridin-2-yl)pyrimidine

Product 1

HCID 22732505HCID 22732505, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-6-methyl-2-(2-pyridinyl)pyrimidine (50 mg, 0.243 mmol) and 3-methoxyphenol (27 μl, 0.243 mmol) similar to Example 13 and isolated as a white oil (24 mg, 34%). 1H NMR (CDCl3): 8.79–8.76 (m, 1H), 8.26–8.23 (m, 1H), 7.75–7.69 (m, 1H), 7.33–7.28 (m, 2H), 6.82–6.72 (m, 3H), 6.58 (s, 1H), 3.77 (s, 3H), 2.58 (s, 3H).

Sources & evidence

ORD record
ord-c67d0478856d4b349ef570d51f09575f
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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