3-Aminophenol → HCID 22732425, compound

HRID 1765201Notes

Reaction equation

HRID 1765201 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[N:3]=1.[NH2:18][C:19]1[CH:20]=[C:21]([OH:25])[CH:22]=[CH:23][CH:24]=1>>[ClH:1].[OH:25][C:21]1[CH:20]=[C:19]([CH:24]=[CH:23][CH:22]=1)[NH:18][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[N:3]=1

Participants

3

Reactant 2

HCID 115683-AminophenolHCID 227323674-Chloro-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732425HCID 22732425, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.192 mmol) and 3-aminophenol (31 mg, 0.288 mmol) similar to Example 97 and isolated as a tan solid (28 mg,). 1H NMR (DMSO-d6): 10.26 (s, 1H), 9.62 (s, 1H), 9.51–9.50 (m, 1H), 8.87–8.83 (m, 2H), 7.30 (s, 1H), 7.23–7.21 (m, 3H), 6.57–6.54 (m, 1H).

Workup

  1. customisolated as a tan solid (28 mg,)

Sources & evidence

ORD record
ord-c647a36bf2ac40e9bd8b223d710b4811
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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