3,5-Dimethoxyaniline → HCID 22732475, compound

HRID 1765220Notes

Reaction equation

HRID 1765220 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:24]=[C:25]([O:27][CH3:28])[CH:26]=1)[NH2:23]>>[ClH:1].[CH3:28][O:27][C:25]1[CH:24]=[C:22]([CH:21]=[C:20]([O:19][CH3:18])[CH:26]=1)[NH:23][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1

Participants

3

Reactant 2

HCID 663013,5-DimethoxyanilineHCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732475HCID 22732475, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 3,5-dimethoxyaniline (44 mg, 0.290 mmol) similar to Example 117 and isolated as a yellow solid (29 mg, 38%). 1H NMR (DMSO-d6): 10.32 (s, 1H), 9.48–9.46 (m, 1H), 8.76–8.74 (m, 1H), 8.62–8.58 (m, 1H), 7.63–7.58 (m, 1H), 7.14 (s, 1H), 7.06 (s, 2H), 6.32 (s, 1H), 3.80 (s, 6H).

Sources & evidence

ORD record
ord-30d2694804c7477782d4fc7cb7e8a064
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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