Ethanone, 1-(2-amino-4,5-dimethoxyphenyl)- → HCID 22732513, compound

HRID 1765231Notes

Reaction equation

HRID 1765231 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[CH3:18][C:19]([C:21]1[C:26]([NH2:27])=[CH:25][C:24]([O:28][CH3:29])=[C:23]([O:30][CH3:31])[CH:22]=1)=[O:20]>>[C:19]([C:21]1[CH:22]=[C:23]([O:30][CH3:31])[C:24]([O:28][CH3:29])=[CH:25][C:26]=1[NH:27][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1)(=[O:20])[CH3:18]

Participants

3

Reactant 2

HCID 602085Ethanone, 1-(2-amino-4,5-dimethoxyphenyl)-HCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732513HCID 22732513, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 2-amino-4,5-dimethoxyacetophenone (56 mg, 0.290 mmol) similar to Example 117 and isolated as a tan solid (24 mg, 30%). 1H NMR (CDCl3): 12.49 (s, 1H), 9.65–9.64 (m, 1H), 8.86 (s, 1H), 8.74–8.70 (m, 2H), 7.45–7.41 (m, 1H), 7.35 (s, 1H), 6.99 (s, 1H), 4.12 (s, 3H), 3.95 (s, 3H), 2.68 (s, 3H).

Sources & evidence

ORD record
ord-cea8ece323b049b38a31f9c1a846e0ff
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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