4-Chloro-2,5-dimethoxyaniline → HCID 22732435, compound

HRID 1765246Notes

Reaction equation

HRID 1765246 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[N:3]=1.[Cl:18][C:19]1[C:25]([O:26][CH3:27])=[CH:24][C:22]([NH2:23])=[C:21]([O:28][CH3:29])[CH:20]=1>>[ClH:1].[Cl:18][C:19]1[C:25]([O:26][CH3:27])=[CH:24][C:22]([NH:23][C:2]2[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)[N:3]=2)=[C:21]([O:28][CH3:29])[CH:20]=1

Participants

3

Reactant 2

HCID 228334-Chloro-2,5-dimethoxyanilineHCID 113115004-Chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732435HCID 22732435, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 4-chloro-2,5-dimethoxyaniline (54 mg, 0.290 mmol) similar to Example 117 and isolated as a brown solid (58 mg, 73%). 1H NMR (CDCl3): 8.84–8.82 (m, 1H), 8.61–8.57 (m, 1H), 7.93–7.87 (m, 1H), 8.50 (bs, 1H), 7.66 (s, 1H), 7.49–7.45 (m, 1H), 7.02 (s, 1H), 7.01 (s, 1H), 4.07 (s, 3H), 3.92 (s, 3H).

Sources & evidence

ORD record
ord-d8218dfe20a8482cb7abf0ca96636343
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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