4,5-Dimethoxy-2-methylaniline → HCID 22732400, compound

HRID 1765248Notes

Reaction equation

HRID 1765248 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[N:3]=1.[CH3:18][O:19][C:20]1[C:26]([O:27][CH3:28])=[CH:25][C:23]([NH2:24])=[C:22]([CH3:29])[CH:21]=1>>[ClH:1].[CH3:18][O:19][C:20]1[C:26]([O:27][CH3:28])=[CH:25][C:23]([NH:24][C:2]2[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)[N:3]=2)=[C:22]([CH3:29])[CH:21]=1

Participants

3

Reactant 2

HCID 2665854,5-Dimethoxy-2-methylanilineHCID 113115004-Chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732400HCID 22732400, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 4,5-dimethoxy-2-methylaniline (48 mg, 0.290 mmol) similar to Example 117 and isolated as a yellow solid (64 mg, 79%). 1H NMR (CDCl3): 8.82–8.80 (m, 1H), 8.55 (d, J=7.8 Hz, 1H), 7.88–7.82 (m, 1H), 7.51 (s, 1H), 7.43–7.38 (m, 1H), 6.80 (s, 1H), 6.76 (s, 1H), 6.50 (s, 1H), 3.92 (s, 3H), 3.84 (s, 3H), 2.19 (s, 3H).

Sources & evidence

ORD record
ord-776cfb00b52643a5941def817d398f89
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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