4,5-Dimethoxy-2-methylaniline → HCID 22732400, compound

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Reaction Steps

The title compound was prepared from a mixture of 4-chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 4,5-dimethoxy-2-methylaniline (48 mg, 0.290 mmol) similar to Example 117 and isolated as a yellow solid (64 mg, 79%). 1H NMR (CDCl3): 8.82–8.80 (m, 1H), 8.55 (d, J=7.8 Hz, 1H), 7.88–7.82 (m, 1H), 7.51 (s, 1H), 7.43–7.38 (m, 1H), 6.80 (s, 1H), 6.76 (s, 1H), 6.50 (s, 1H), 3.92 (s, 3H), 3.84 (s, 3H), 2.19 (s, 3H).

Provenance & Evidence