Pyrazole → 4-(1-Pyrazolyl)-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine

HRID 1765265Notes

Reaction equation

HRID 1765265 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[NH:18]1[CH:22]=[CH:21][CH:20]=[N:19]1>>[N:18]1([C:2]2[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]3[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=3)[N:3]=2)[CH:22]=[CH:21][CH:20]=[N:19]1

Participants

3

Reactant 2

HCID 1048PyrazoleHCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 227323864-(1-Pyrazolyl)-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine

Procedure

The title compound was prepared from 4-chloro-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine (74 mg, 0.285 mmol) and pyrazole (28 mg, 0.425 mmol) similar to Example 166 and was isolated as a white solid (mp 151–152° C., 67 mg, 0.230 mmol, 81%). 1H NMR (CDCl3) 9.71 (s, 1H), 8.77 (m, 3H), 8.19 (s, 1H), 7.88 (m, 1H), 7.47 (m, 1H), 6.61 (dd, J=1.5, 2.7 Hz, 1H).

Sources & evidence

ORD record
ord-e3ad1b68b90e40b1a2fdd56d79b81a61
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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