3-Phenoxyaniline → HCID 22732520, compound

HRID 1765269Notes

Reaction equation

HRID 1765269 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=1.[O:15]([C:22]1[CH:23]=[C:24]([CH:26]=[CH:27][CH:28]=1)[NH2:25])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH3:8][C:6]1[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:3]=[C:2]([NH:25][C:24]2[CH:26]=[CH:27][CH:28]=[C:22]([O:15][C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:23]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 771353-PhenoxyanilineHCID 27633954-Chloro-6-methyl-2-(pyridin-2-yl)pyrimidine

Product 1

HCID 22732520HCID 22732520, compound

Procedure

The title compound was prepared from 4-chloro-6-methyl-2-(2-pyridinyl)pyrimidine (82.3 mg, 0.4 mmol) and 3-phenoxyaniline (74.0 mg, 0.4 mmol) similar to Example 173 and was isolated as a white solid. (96 mg, 68%). 1H NMR (CDCl3): 8.62 (d, J=4.2 Hz, 1H), 8.25 (d, J=8.1 Hz, 1H), 7.65 (t, J=1.5 Hz, 1H), 7.21 (m, 5H), 6.94 (m, 5H), 6.64 (d, J=8.1 Hz, 1H), 6.49 (s, 1H), 2.33 (s, 3H),

Workup

  1. customwas isolated as a white solid

Sources & evidence

ORD record
ord-5f75376990a944b5b8e1ccace74f66e0
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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