HCID 211811, compound → HCID 69456393, compound

HRID 1765294Notes

Reaction equation

HRID 1765294 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[CH3:18][O:19][CH:20]([C:23]1[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[CH:25][CH:24]=1)[CH2:21][NH2:22]>>[CH3:18][O:19][CH:20]([C:23]1[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[CH:25][CH:24]=1)[CH2:21][NH:22][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1

Participants

3

Reactant 2

HCID 211811HCID 211811, compoundHCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 69456393HCID 69456393, compound

Procedure

The title compound was prepared from 4-chloro-2-(3-pyridinyl)-6-trifluoromethylpyrimidine (40 mg, 0.154 mmol) and 2,5-dimethoxyphenylethylamine (28 mg, 0.232 mmol) similar to Example 186 and was isolated as an off white solid (35 mg, 54% yield). 1H NMR (CDCl3): 9.59 (brs, 1H), 8.69 (d, J=4.8 Hz, 1H), 7.37 (dd, J=4.8, 8.4 Hz, 1H), 6.76 (m, 3H), 3.95 (s, 3H), 3.90 (s, 3H), 3.00 (t, 2H), 1.67 (s, 2H).

Sources & evidence

ORD record
ord-9ecb41da3296402687c2617887f4cec9
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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