3,4,5-Trichloroaniline → HCID 22732356, compound

HRID 1765296Notes

Reaction equation

HRID 1765296 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[Cl:18][C:19]1[CH:20]=[C:21]([CH:23]=[C:24]([Cl:27])[C:25]=1[Cl:26])[NH2:22]>>[Cl:18][C:19]1[CH:20]=[C:21]([CH:23]=[C:24]([Cl:27])[C:25]=1[Cl:26])[NH:22][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1

Participants

3

Reactant 2

HCID 124693,4,5-TrichloroanilineHCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732356HCID 22732356, compound

Procedure

The title compound was prepared from 4-chloro-2-(3-pyridinyl)-6-trifluoromethylpyrimidine (50 mg, 0.192 mmol) and 3,4,5-trichloroaniline (56 mg, 0.288 mmol) similar to Example 180 and was isolated as a white solid (30 mg, 37%). 1H NMR (CDCl3): 9.58 (d, J=1.5 Hz, 1H), 8.99 (ddd, J=8.4, 4.9, 1.5 Hz, 1H), 8.79 (dd, J=5.4, 1.5 Hz, 1H), 7.99 (s, 1H), 7.76 (dd, J=7.8, 5.1 Hz, 1H), 7.40 (s, 1H).

Sources & evidence

ORD record
ord-375aa3a13c094e118667876e2066c48f
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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