4-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine → HCID 22732496, compound

HRID 1765298Notes

Reaction equation

HRID 1765298 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[NH2:18][C:19]1[C:24]2[O:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:23]=2[CH:22]=[CH:21][C:20]=1[O:32][CH3:33]>>[CH3:33][O:32][C:20]1[CH:21]=[CH:22][C:23]2[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=3[O:25][C:24]=2[C:19]=1[NH:18][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1

Participants

3

Reactant 2

HCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidineHCID 22732407HCID 22732407, compound

Product 1

HCID 22732496HCID 22732496, compound

Procedure

The title compound was prepared from 4-chloro-2-(3-pyridinyl)-6-trifluoromethylpyrimidine (50 mg, 0.192 mmol) and 4-amino-3-methoxydibenzofuran (61 mg, 0.288 mmol) similar to Example 185 and was isolated as a solid (6 mg, 7%). 1H NMR (CDCl3): 9.73 (brs, 1H), 8.88 (d, J=7.8 Hz, 1H), 8.77 (brs, 1H), 7.89 (m, 1H), 7.19–7.59 (m, 6H), 7.02 (s, 1H), 4.05 (s, 3H).

Sources & evidence

ORD record
ord-1e30cf9c36ed4cd7b5cb121655a6575f
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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