Methyl iodide → HCID 58883429, compound

HRID 1765317Notes

Reaction equation

HRID 1765317 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][N:7]=1.IC.[CH3:17]C(C)([O-])C.[K+]>>[CH3:17][N:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6]([C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)=[N:7]1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 10888604HCID 10888604, compound2×HCID 23665647Potassium tert-butoxide

Product 1

HCID 58883429HCID 58883429, compound

Procedure

N-Methylfuranylindazole B was prepared from furanylindazole A and iodomethane in the presence of potassium t-butoxide at room temperature. Vilsmier-Haack reaction (POCl3/DMF) of furanylindazole B gave the corresponding aldehyde D which was then subjected to NaBH4 reduction to give the title compound 2.

Sources & evidence

ORD record
ord-19857d1d49b14663965850f58ef106f4
Source dataset
uspto-grants-2007_06
Patent number
US07226941B2

Reaction notes

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