HCID 21106512, compound → HCID 21106487, compound

HRID 1765360Notes

Reaction equation

HRID 1765360 reaction equation
C(OC([N:8]([C:26]1[CH:30]=[C:29]([CH3:31])[N:28](C(OC(C)(C)C)=O)[N:27]=1)[C:9]1[C:18]2[C:13](=[CH:14][C:15]([C:19]([OH:21])=[O:20])=[CH:16][CH:17]=2)[C:12](=[O:22])[N:11]([CH:23]([CH3:25])[CH3:24])[N:10]=1)=O)(C)(C)C>FC(F)(F)C(O)=O>[CH:23]([N:11]1[C:12](=[O:22])[C:13]2[C:18](=[CH:17][CH:16]=[C:15]([C:19]([OH:21])=[O:20])[CH:14]=2)[C:9]([NH:8][C:26]2[CH:30]=[C:29]([CH3:31])[NH:28][N:27]=2)=[N:10]1)([CH3:25])[CH3:24]

Participants

3

Reactant 1

HCID 21106512HCID 21106512, compound

Product 1

HCID 21106487HCID 21106487, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

1-[tert-Butoxycarbonyl-(1-tert-butoxycarbonyl-5-methyl-1H-pyrazol-3-yl)-amino]-3-isopropyl-4-oxo-3,4-dihydro-phthalazine-6-carboxylic acid (13.0 mg, 0.02 mmol) was dissolved in a 20% trifluoroacetic acid (TFA)/DCM solution (2 ml) and the reaction mixture was stirred for 48 hours. After this time, the reaction mixture was concentrated and the resulting residue was triturated with diethyl ether to give the title compound (Example M-1) as a white solid.

Workup

  1. concentrationAfter this time, the reaction mixture was concentrated
  2. customthe resulting residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-2ebb3d9273584949827f8ab9312cb045
Source dataset
uspto-grants-2007_06
Patent number
US07226923B2

Reaction notes

Loading…