Dichloromethane → Dichloromethane heptane

HRID 1765386Notes

Reaction equation

HRID 1765386 reaction equation
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)C(=O)N(C2C=CC(SC3C=CC=CC=3)=CC=2)N=1.C1C=C(Cl)C=C(C(OO)=O)C=1.[Cl:37][CH2:38][Cl:39]>>[CH3:2][CH2:11][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[Cl:37][CH2:38][Cl:39]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 70297m-Chloroperbenzoic acidHCID 21106556HCID 21106556, compound

Product 1

HCID 21907733Dichloromethane heptaneYield 31%

Procedure

4-Bromo-2-(4-phenylsulfanyl-phenyl)-2H-phthalazin-1-one (0.095 g, 0.23 mmol) and MCPBA (0.052 g, 0.23 mmol) were stirred at room temperature in dichloromethane (1 ml) for 1 h. The tide compound was obtained after evaporation of the solvent in vacuum and subsequent purification of the raw product by chromatography over silica gel with heptane:dichloromethane (1:1 until 0:1) (0.031 g, 31% yield). 1H-NMR: (400 MHz, CDCl3) 8.49 (1H, d), 7.80–7.99 (5H, m), 7.76 (2H, d), 7.69 (2H, d), 7.48 (3H, m); MS (ESI+)=427.22 (M+H)+.

Workup

  1. customThe tide compound was obtained
  2. customafter evaporation of the solvent

Sources & evidence

ORD record
ord-6e4800b84ec24d55b127d097b6012ca7
Source dataset
uspto-grants-2007_06
Patent number
US07226923B2

Reaction notes

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